Dr. Michael D. Shapiro is a faculty member in the Section of Cardiovascular Medicine at Wake Forest University School of Medicine whose clinical interests focus on genetic and acquired disorders of cholesterol, triglycerides and atherosclerosis, cardiovascular imaging, genetic predispositions to early myocardial infarction, and cardiovascular risk assessment in apparently healthy individuals. Dr. Shapiro has published extensively in the areas of atherosclerosis imaging, lipid disorders, and preventive cardiology. He investigates PCSK9 physiology and its impact on lipoprotein metabolism, metabolomics of atherosclerosis, developing and validating automated quantification of breast arterial calcification to refine cardiovascular risk estimation in women, and identifying individuals with familial hypercholesterolemia using machine learning algorithms.