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CARDIOLOGY

Session Topic

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SPEAKER NAME and Credentials

CARDIOLOGY

Session Topic

short description short description short description short description short description short description short description

SPEAKER NAME and Credentials

CARDIOLOGY

Session Topic

short description short description short description short description short description short description short description

SPEAKER NAME and Credentials

CARDIOLOGY

Session Topic

short description short description short description short description short description short description short description

SPEAKER NAME and Credentials

DON’T MISS THESE TOPICS AND MORE!

Agenda
Friday, May 19, 2023
Lifestyle, Diet, Physical Activity and Inflammation
8:00 AM — 8:05 AM
Welcome and Introduction
Robert H. Eckel, MD
8:05 AM — 8:25 AM
Nutrition, inflammation and cardiometabolic disease
Pam R. Taub, MD, FACC, FASPC
8:25 AM — 8:45 AM
Physical activity and impact on chronic inflammation and cardiometabolic health: exploring the links & evidence
Carl J. Lavie, MD, FACC
8:45 AM — 9:05 AM
Stress management, sleep & recovery
Virend Somers, MD, PhD
9:05 AM — 9:25 AM
Genetic Testing for Early Hypertension, Dyslipidemia, DM and CHD
Mark C. Houston, MD, MS, FACP, ABAARM
9:25 AM — 9:45 AM
Transition of NAFLD to NASH: inflammation is the culprit
Stephen A. Harrison, MD
9:45 AM — 10:30 AM
Expert Panel Discussion and Q & A
Moderator: Robert H. Eckel, MD
Panelists: Stephen A. Harrison, MD; Mark C. Houston, MD, MS, FACP, ABAARM; Carl J. Lavie, MD, FACC; Virend Somers, MD, PhD; Pam R. Taub, MD, FACC, FASPC
10:30 AM — 11:00 AM
Break
11:00 AM — 12:00 PM
PME Lunch Symposium (Non-CME)
Circadian bromocriptine-QR therapy attenuates elevated sympathetic tone, postprandial dysmetabolism, and an immune proinflammatory state and reduces adverse cardiovascular event rate: Clinical studies summary in T2DM subjects
Sponsored by VeroScience.
Anthony H. Cincotta, PhD
12:00 PM – 1:00 PM
Break & Exhibit Hall
Cardiovascular Disease
1:00 PM
Introductions
Christie M. Ballantyne, MD
1:00 PM – 1:40 PM
Keynote Address: Inflammation and immunity in aging and atherothrombosis
Peter Libby, MD
1:40 PM – 2:20 PM
Inflammation and atherosclerosis: current and future approaches for clinical interventions
Paul M. Ridker, MD, MPH
2:20 PM – 2:50 PM
The impact of inflammation in heart failure: prevention, testing, and treatment
Ileana Piña, MD, MPH
2:50 PM – 3:20 PM
Links between systemic inflammation and cardiovascular disease: focus on cardio-rheumatology
Brittany N. Weber, MD, PhD
3:20 PM – 4:00 PM
Expert Panel Discussion and Q & A
Moderator: Christie M. Ballantyne, MD
Panelists: Peter Libby, MD; Pamela B. Morris, MD; Ileana Piña, MD, MPH; Paul M. Ridker, MD, MPH; Brittany N. Weber, MD, PhD
4:00 PM – 6:00 PM
Break & Exhibit Hall
Saturday, May 20, 2023
Hypertension, Lipids, and Obesity
8:00 AM — 8:05 AM
Day 2 Opening Remarks
Pamela B. Morris, MD
8:05 AM — 8:25 AM
Inflammation and hypertension: novel mechanistic insights
George L. Bakris, MD
8:25 AM — 8:50 AM
Lipoproteins and Inflammation – Focus on LDL, Lp(a) and TG rich lipoproteins and new therapies in development
Christie M. Ballantyne, MD
8:50 AM — 9:15 AM
Obesity, Inflammation and Cardiovascular Risk
Erin D. Michos, MD, MHS, FAHA, FACC, FASE, FASPC
9:15 AM — 10:00 AM
Expert Panel Discussion and Q & A
Moderator: Pamela B. Morris, MD
Panelists: Christie M. Ballantyne, MD; George L. Bakris, MD; Robert H. Eckel, MD; Erin D. Michos, MD, MHS, FAHA, FACC, FASE, FASPC
10:00 AM – 11:00 AM
Break
11:00 AM – 12:00 PM
PME Lunch Symposium (Non-CME)
A Treatment Option for Patients with Heart Failure
Sponsored by AstraZeneca.
Victor N. Howard, MD, FACC
12:00 PM – 1:00 PM
Break & Exhibit Hall
Type 2 Diabetes and Kidney Disease
1:00 PM
Introductions
Robert H. Eckel, MD
1:00 PM – 1:25 PM
Is there a role of inflammation in type 2 diabetes pathogenesis?
Sam Dagogo-Jack, MD, DSc
1:25 PM – 1:50 PM
CKD, T2DM and inflammation: pathogenesis and more
Jennifer Green, MD
1:50 PM – 2:15 PM
Prevention, screening and treatment of chronic kidney disease
Rajiv Agarwal, MD
2:15 PM – 3:00 PM
Expert Panel Discussion and Q & A
Moderator: Robert H. Eckel, MD
Panelists: Jennifer Green, MD; Rajiv Agarwal, MD; Sam Dagogo-Jack, MD, DSc
3:00 PM – 4:30 PM
Break & Exhibit Hall
Register Now!

2023 CMHC Spring Registration

$195.00

Gaylord Palms Resort & Convention Center in Orlando

Rate: $379

Deadline: January 16, 2023

Phone: 888-879-0462
(Mention Cardiometabolic Health Congress to get our group rate)

PROSPECTUS

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FAQ's

Here are some common questions we’ll answer NOW, the rest you can ask the experts this May 19-20, 2023, in Orlando!

A: Low-grade systemic inflammation precedes the onset of cardiovascular events by many years, and inflammation is a consistent predictor of cardiovascular risk.

A: A large body of clinical data shows that reducing inflammation has cardiometabolic benefits, and reducing inflammation remains an active area of research that also has important clinical implications, including in the prevention and management of obesity, dyslipidemia, heart failure, chronic kidney disease, hypertension, and type 2 diabetes.

A: An excess of macronutrients in the adipose tissues stimulates inflammatory mediators such as tumor necrosis factor α and interleukin 6; it also reduces the production of adiponectin, promoting inflammation and oxidative stress.

A: Inflammation is a primary mechanism in developed cardiometabolic diseases including coagulation, atherosclerosis, metabolic syndrome, insulin resistance and type 2 diabetes. It is also associated with the development of diseases such as psoriasis, depression, cancer, and renal diseases, conditions that often occur comorbidly in people with cardiometabolic conditions.

A: The activation of nuclear factor kappa B (NF-κB) links pathogenic and cellular danger signals, organizing cellular resistance to perceived threats and triggering inflammation.

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Nutrition, inflammation and cardiometabolic disease

Nutrition plays a crucial role in modulating inflammation, a key contributor to chronic cardiometabolic diseases. Several dietary guidelines recommend limiting foods high in sugar, saturated fat, sodium, and cholesterol based on clinical evidence showing individuals who consume these foods have a higher incidence of developing cardiometabolic disease and higher rates of morbidity and mortality from existing type 2 diabetes, coronary heart disease, and kidney failure.

Physical activity and impact on chronic inflammation
and cardiometabolic health: exploring the links & evidence

Physical activity is a vital regulator of inflammation which can negatively impact cardiometabolic health. The latest physical activity guidelines, released in 2018 by the U..S Department of Health and Human Services, provide information on the types and amounts of physical activity that provide substantial health benefits and improve cardiometabolic function via inflammatory regulation.

Stress management, sleep & recovery

Stress, sleep-wake patterns, and disordered sleep affect metabolism function, decision-making, and key disease markers such as inflammatory levels. Along with other underlying pathways, these factors exacerbate many of the contributing factors of cardiometabolic disease. Lifestyle modifications play a key role in the prevention and treatment of cardiometabolic disorders, and in addition to nutrition and physical activity, stress management and sleep are key behaviors affecting cardiometabolic health.

Transition of NAFLD to NASH: Inflammation is the culprit

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome (MetS), defined as the accumulation of fat in the liver in patients who do not consume alcohol. Nonalcoholic steatohepatitis (NASH) is the most aggressive subtype of NAFLD, which is characterized by inflammation, cell damage, and fat on the liver that can lead to complications like liver cancer and cirrhosis. Clinicians must be educated about the pathogenesis, emerging diagnostics approaches, and best practices for the management of NAFLD and NASH.

Inflammation and immunity in aging and atherothrombosis

Atherosclerosis involves the interplay between several pathophysiological processes, including dyslipidemia, endothelial dysfunction, and inflammation. Cardiovascular mortality is the leading cause of mortality and reduced quality of life worldwide. Several preclinical and clinical studies have identified cardiovascular risks as chronic inflammatory disorders and contributed by various inflammatory cells to vascular oxidative stress. Therefore, it is imperative for clinicians to understand the science behind the close association of inflammation and oxidative stress with atherosclerosis and cardiovascular disorders.

Inflammation and atherosclerosis: current and future approaches for clinical interventions

Recent clinical trials such as CANTOS (canakinumab), COLCOT (colchicine), and RESCUE (ziltivekimab) demonstrate significant adverse cardiovascular event reduction using interleukin or tubulin polymerization inhibitors. These agents markedly reduced biomarkers of inflammation and thrombosis relevant to atherosclerosis in patients with elevated inflammatory markers such as C-reactive protein.

The impact of inflammation in heart failure:
prevention, testing, and treatment

Chronic inflammation is one of the main pathophysiological contributors to heart disease; TNF-α, IL-1, IL-6, IL-8, IL-10, IL-18, and C-reactive protein are some of the primary inflammatory mediators in heart failure. Anti-inflammatory therapies such as cytokines, prednisone, and colchicine have been tested in patients with heart failure. Clinicians must understand the underlying role of inflammation in heart failure, its prevention, diagnosis, and emerging treatments.

 Links between systemic inflammation and cardiovascular disease: focus on cardio-rheumatology

Markers of inflammation are commonly observed in patients who’ve had a heart attack or stroke. Although not completely understood, systemic inflammation could be a sign of an atherogenic response to a buildup of plaque in the arteries. Lifestyle factors like a diet high in red meat, and alcohol and tobacco use are known to trigger an inflammatory response and are also considered risk factors for cardiovascular disease, but are there less obvious links between cardiovascular disease and inflammation?

Inflammation and hypertension: novel mechanistic insights

The link between inflammation and blood pressure, demonstrated by mechanistic and basic studies, has implications for current and future treatments for hypertension. The crucial role inflammation plays in the development of hypertension has led not only to a greater understanding of the connection between inflammation and chronic disease but also for the identification of novel targets, particularly for resistant hypertension.

Lipoproteins and inflammation – focus on LDL, Lp(a) and TG-rich
lipoproteins and new therapies in development

Lipid accumulation and resulting inflammation are closely linked to the development of atherosclerotic cardiovascular disease (ASCVD). Low-density lipoprotein cholesterol (LDL-C), triglycerides, and lipoprotein (a) (Lp(a) among others, play a crucial role in the development and progression of ASCVD, and the lipid-lowering field is constantly changing, with several new and emerging targeted therapies.

Obesity, Inflammation and Cardiovascular Risk

The link between chronic inflammation and obesity is strong, and both are risk factors for adverse cardiovascular events. In recent years, significant progress has been made in the treatment of obesity, including the approval of semaglutide 2.4mg and the potential approval of tirzepatide, which have been shown to not only lower body weight, but also reduce inflammatory and cardiometabolic risk. This session will overview some of these connections and the newer tools to address obesity, chronic inflammation, and cardiovascular risk.

Is there a role of inflammation in type 2 diabetes pathogenesis?

The intersections of chronic inflammation and obesity, increased adipose tissue, and impaired beta cell function illustrates the link between inflammation and type 2 diabetes (T2D). This complex relationship has important implications for diabetes development, progression, and current tools and treatment.

CKD, T2DM, and Inflammation: Pathogenesis and More

Patients with type 2 diabetes (T2DM) and chronic kidney disease (CKD) are at an increased risk of cardiovascular and renal disease morbidity and mortality. An important target for CKD was recently approved: nonsteroidal mineralocorticoid receptor antagonists (MRAs). In large phase 3 trials, MRAs improved cardiovascular and renal outcomes by targeting the inflammation and fibrosis in the kidney that results from overactive mineralocorticoid receptors.

Prevention, screening and treatment for chronic kidney disease

Chronic kidney disease (CKD) has high morbidity and mortality, and its development and progression are tightly linked to cardiometabolic risk. Clinicians must be aware of appropriate screening, diagnosis, and management strategies in this condition to prevent adverse renal and cardiovascular outcomes.