Dr. Roe has served as the principal investigator at the Duke Clinical Research Institute (DCRI) Coordinating Center for numerous clinical trials investigating anti-platelet therapies for acute myocardial infarction (MI) as well as myocardial protection agents designed to ameliorate reperfusion injury in patients with acute ST-elevation MI. Additionally, Dr. Roe has served as the co-principal investigator for the CRUSADE national quality improvement initiative performed at almost 500 hospitals in the United States from 2001-2006.  Dr. Roe is the previous Chairman of the Research and Publications Sub-Committee for the American College of Cardiology (ACC) ACTION Registry-GWTG program (2007-2010) evaluating care patterns for patients with acute MI at hospitals across the United States. Dr. Roe is currently a member of the ACC Cath-PCI Registry Research and Publications Sub-Committee and the ACC National Cardiovascular Date Registry Scientific Oversight Committee (2009-Present). 

Dr. Roe has served as the Director of the DCRI’s fellowship program since 2006.  In this capacity, Dr. Roe has contributed to an expansion of the fellowship program to approximately 15-20 fellows per year from a variety of medical specialties including cardiology, pediatrics, nephrology, gastroenterology, and neurology. Dr. Roe supervises the faculty mentorship program for cardiology research fellows, has developed a standardized approach to the assessment of DCRI faculty mentorship of research fellows, and has won the Robert M. Califf Mentorship Award in 2008 (awarded annually by the DCRI research fellows to the best faculty mentor in each academic year).